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There's also the Big "M" casino boat, which departs twice daily for fun and gambling on the Gulf of Mexico. You can also take a trip on the Key West Express and get Key West in three hours. You can return the same day, or stay in Key West for a few days and return to Fort Myers Beach at a later time. The boat leaves Fort Myers Beach at 10 a.m., and leaves Key West at 6 p.m.